L-Carnitine L - Tartarate + Mecobalamin + Folic Acid Tablets

Mechanism

• L-Carnitine: Carnitine and weight loss: L-carnitine is a potent fat burner because it is responsible for the transport of fats into the cells to be used for energy in the body. By raising the level of muscle carnitine, support fat burning process, increases energy levels.
  Prevents type 2 diabetes and improve insulin health: Carnitine is emerging as a supplement that can prevent type2 diabetes because it improves fat metabolism. It counters the disease of metabolic syndrome by preventing atherosclerosis and supporting cardiovascular health.
  Male infertility: low sperm counts have been linked to low carnitine levels in men. Carnitine supplement may increase sperm count and motility.
  Hyperthyroidism: L- carnitine may helps prevent or reduce symptoms of an overactive thyroid, such as insomnia, nervousness, heart palpitation and tremors.L-carnitine burns fat by promoting movement of fatty acids into the mitochondria, which burns fatty acids to make energy. Fatty acids cannot move into the mitochondria without L-carnitine.
• Folic acid: It is a form of the water soluble vitamin B9. Folic acid is a key factor in synthesis of nucleic acid ultimately synthesizes DNA & RNA. It prevents folate deficiency. Folate deficiency may lead to peripheral neuropathy, insomnia, dementia and depression.
  
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• Methylcobalamin: It is the potent form of vitamin B12,system being also very important for cell growth and production. It is neurologically active form of the vitamin B12.
  Methylcobalamin is used in variety of processes, including: production of red and white blood cell, the regeneration of RNA and DNA, synthesis of proteins, nerve cell and sheath maintance and maintenance of bone marrow.
  It is used in treatment of the peripheral neuropathy, diabetic neuropathy, and people deficient in vitamin B12.

Pharmacokinetics

• Absorption: L-Carnitine absorbed via active transport; CoQ10 absorbed with dietary fat; Magnesium absorbed variably depending on salt form.
• Distribution: L-Carnitine concentrated in skeletal muscle; CoQ10 in heart, liver, kidneys; Magnesium in bone and muscle.
• Metabolism: L-Carnitine minimally metabolized; CoQ10 metabolized in liver; Magnesium not metabolized.
• Excretion: L-Carnitine via urine; CoQ10 via bile; Magnesium via urine and feces.

Side Effects

• Mild gastrointestinal upset
• Headache
• Fatigue (rare)

Contraindication

• Hypersensitivity to any component
• Severe renal impairment
• Pregnancy/lactation unless prescribed

Interaction

• Statins: May reduce endogenous CoQ10 levels; supplementation beneficial.
• Antihypertensives: CoQ10 may enhance blood pressure-lowering effect.
• Diuretics: May increase magnesium loss.
• Valproic acid: May lower carnitine levels.

Warning and Precautions

• Monitor patients on anticoagulants for bleeding risk.
• Use with caution in renal impairment.
• Take with meals containing fat for better absorption of CoQ10.
• Not recommended for children unless prescribed.

Dosage

As directed by the Dietician.